Precision Tissue Analysis for Preclinical & Translational Research
At HT Biotechnology, our Histopathology Platform offers end-to-end solutions for tissue processing, staining, and advanced imaging. Combining cutting-edge technologies with GLP-compliant workflows, we deliver high-resolution morphological and molecular insights to accelerate drug development, validate medical devices, and advance disease modeling.
Core Services
Tissue Sectioning & Preparation
- Paraffin Sectioning: Optimal preservation of tissue architecture for long-term studies.
- Frozen Sectioning: Rapid cryosectioning for lipid-rich tissues (e.g., brain, adipose) and enzyme activity assays.
- Hard Tissue Sectioning: Precision cutting of bone, teeth, and calcified tissues for orthopedic/dental research.
Staining & Molecular Profiling
- Routine Staining: H&E Staining
- Special Stains:
Masson’s Trichrome: Collagen/fibrosis visualization.
PASM (Periodic Acid–Schiff–Methenamine): Basement membranes, fungal elements.
Silver Nitrate Staining: Neural fibers, microorganisms.
Van Gieson (VG): Elastic fiber differentiation.
Key Applications
|
Research Area |
Service Highlights |
|
Oncology |
Tumor grading, TILs analysis, metastasis detection. |
|
Fibrotic Diseases |
Collagen deposition scoring (Masson’s trichrome), hepatic/renal fibrosis staging. |
|
Neurodegeneration |
Amyloid plaque/tangle quantification (IHC/IF), myelin integrity assessment. |
|
Toxicopathology |
Necrosis, inflammation, and hyperplasia scoring for safety assessments. |
|
Medical Device Testing |
Tissue integration/biocompatibility analysis (ISO 10993). |
